EXPERIMENTELLE PÄDIATRIE UND NEONATOLOGIE

Publikationen

2020

Korthals M, Tech L, Langnaese K, Gottfried A, Hradsky J, Thomas U, Zenclussen AC, Brunner-Weinzierl MC, Tedford K, Fischer KD. 2020. Plasma membrane Ca2+ ATPase 1 (PMCA1) but not PMCA4 is critical for B-cell development and Ca2+ homeostasis in miceEur J Immunol. 2020 Oct 24. https://doi.org/10.1002/eji.202048654. Online ahead of print. PMID: 33098669

Knolle J, Pierau M, Hebel K, Lampe K, Jorch G, Kropf S, Arens C, Brunner-Weinzierl MC. 2020. Children from the age of three show a developmental switch in T-cell differentiation. Frontiers in immunology. 11: 1640. https://doi.org/10.3389/fimmu.2020.01640

Meltendorf S, Fu H, Pierau M, Lindquist J, Finzel S, Mertens PR, Ambach A, Thomas U, Lingel H, Voll RE, Brunner-Weinzierl MC. 2020. Cell Survival Failure in Effector T Cells From Patients With Systemic Lupus Erythematosus Following Insufficient Up-Regulation of Cold-Shock Y-Box Binding Protein 1. Arthritis & rheumatology (Hoboken, N.J.). https://doi.org/10.1002/art.41382

Pierau M, Lingel H, Vogel K, Arra A, Brunner-Weinzierl MC. 2020. CTLA-4-competent conventional T-cells back up regulatory T-cells to restrain memory T-helper type 2 cell responses. Allergy. 75(3): 684–687. https://doi.org/10.1111/all.14042

2019

Lingel H, Brunner-Weinzierl MC. 2019. CTLA-4 (CD152): A versatile receptor for immune-based therapy. Seminars in Immunology. 2019 Apr; 42:101298. Review. PMID: 31604536. https://doi.org/10.1016/j.smim.2019.101298

Pierau M, Lingel H, Vogel K, Arra A, Brunner-Weinzierl MC. 2019. CTLA-4-competent conventional T-cells back up regulatory T-cells to restrain memory T-helper type 2 cell responses. Allergy. 2019 Sep 10. doi: 10.1111/all.14042. [Epub ahead of print] No abstract available. PMID: 31505050. https://doi.org/10.1111/all.14042

Yshii L, Pignolet B, Mauré E, Pierau M, Brunner-Weinzierl MC, Hartley O, Bauer J, Liblau R. 2019. IFN-γ is a therapeutic target in paraneoplastic cerebellar degeneration.JCI Insight. 2019 Apr 4;4(7). pii: 127001. doi: 10.1172/jci.insight.127001.eCollection 2019 Apr 4. PMID: 30944244. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6483638/pdf/jciinsight-4-127001.pdf

2018

Brunner-Weinzierl MC, Rudd CE. 2018. CTLA-4 and PD-1 Control of T-Cell Motility and Migration: Implications for Tumor Immunotherapy. Front Immunol 9: link: https://doi.org/10.3389/fimmu.2018.02737

Vogel K, Pierau M, Arra A, Lampe K, Schlüter D, Arens C, Brunner-Weinzierl MC. 2018. Developmental induction of human T-cell responses against Candida albicans and Aspergillus fumigatus. Sci Rep 8: 16904. link: https://www.ncbi.nlm.nih.gov/pubmed/30442915

Brunner-Weinzierl MC, Kopp M. 2018. Paradigmenwechsel in der Allergieprävention. Monatsschrift Kinderheilkunde: Organ der Deutschen Gesellschaft für Kinderheilkunde - Berlin: Springer, Bd. 166.2018, 8, S. 708-713. link: https://www.springermedizin.de/paediatrische-allergologie/stillen--saeuglingsnahrung--beikost/paradigmenwechsel-in-der-allergiepraevention/15768050

Lingel H, Schanze D, Zenker M, Brunner-Weinzierl MC.  2018. Translation-inhibitor PDCD4-bound mRNAs in CD8+ T lymphocytes. Repositorium OVGU. DOI 10.24352/UB.OVGU-2018-143 

2017

Lingel H, Wissing J, Arra A, Schanze D, Lienenklaus S, Klawonn F, Pierau M, Zenker M, Jänsch L, Brunner-Weinzierl MC. 2017. CTLA-4-mediated post-translational modifications direct cytotoxic T lymphocyte differentiation. Cell Death Differ 24, 1739–1749

Arra A, Lingel H, Kuropka B, Pick J, Schnoeder T, Fischer T, Freund C, Pierau M, Brunner-Weinzierl MC. 2017. The differentition and plasticity of Tc17 cells are regulated by CTLA-4-mediated effects on STATs. Oncoimmunol 6:e1273300

Bernhardt A, Fehr A, Brandt S, Jerchel S, Ballhause TM, Philipsen L, Stolze S, Geffers R, Weng H, Fischer KD, Isermann B, Brunner-Weinzierl MC, Batra A, Siegmund B, Zhu C, Lindquist JA, Mertens PR. 2017. Inflammatory cell infiltration and resolution of kidney inflammation is orchestrated by the cold-shock protein Y-box binding protein-1. Kidney Int 92:1157-1177

Ranjan S, Goihl A, Gadi I, Kohli S, Pierau M, Shahzad K, Bock F, Wang H, Shaikh H, Reinhold D, Zenclusen A, Brunner-Weinzierl MC, Fischer T, Kalinski T, Schraven B, Luft T, Hühn J, Heidel FH, Isermann B. 2017. Activated protein C protects from GvHD via PAR2/PAR3 signalling in regulatory T-cells. Nat Commun  8:311

Gieseler-Halbach S, Meltendorf S, Pierau M, Weinert S, Heidel FG, Fischer T, Handschuh J, Braun-Dullaeus RC, Schrappe M, Lindquist JA, Mertens PR, Thomas U, Brunner-Weinzierl MC. 2017. RSK-mediated nuclear accumulation of the cold-shock Y-box protein-1 controls proliferation of T cells in T-ALL blasts. Cell Death Differ 24: 371-383

2016

Cammann C, Rath A, Reichl U, Lingel H, Brunner-Weinzierl MC, Simeoni L, Schraven B, Lindquist JA. 2016. Early changes in the metabolic profile of activated CD8+ T cells. BMC Cell Biol 17: 28.

Schmiedeberg K, Krause K, Röhl FW, Hartig R, Jorch G, Brunner-Weinzierl MC. 2016. T cells of infants are mature, but hyporeactive due to limited Ca2+ influx. PLoS ONE 11:e0166633.

Yshii LM, Gebauer CM, Pignolet B, Mauré E, Quériault C, Pierau M, Saito H, Suzuki N, Brunner-Weinzierl MC, Bauer J, Liblau R. 2016. CTLA4 blockade elicits paraneoplastic neurological disease in a mouse model. BRAIN 139: 2923-2934.

2014

Pick J, Arra A, Lingel H, Hegel JK, Huber M, Nishanth G, Jorch G, Fischer KD, Schlüter D, Tedford K, Brunner-Weinzierl MC. 2014. CTLA-4 (CD152) enhances the Tc17 differentiation program. Eur J Immunol 44: 2139-2152.

Hebel K, Weinert S, Kuropka B, Knolle J, Kosak B, Jorch G, Arens C, Krause E, Braun-Dullaeus R, Brunner-Weinzierl MC. 2014. CD4+ T cells from Human Neonates and Infants Are Poised Spontaneously To Run a Nonclassical IL-4 program. J Immunol 192:5160-5170.

Stojanovic A, Fiegler N, Brunner-Weinzierl MC, Cerwenka A. 2014. CTLA-4 is expressed by activated mouse NK cells and inhibits NK Cell IFN-y production in response to mature dendritic cells. J Immunol 192:4184-4191.

Wolleschak D, Mack TS, Perner F, Frey S, Schnöder TM, Wagner MC, Höding C, Pils MC, Parkner A, Kliche S, Schraven B, Hebel K, Brunner-Weinzierl MC, Ranjan S, Isermann B, Lipka DB, Fischer T, Heidel FH. 2014. Clinically relevant doses of FLT3-kinase inhibitors quizartinib and midostaurin do not impair T-cell reactivity and function. Haematologica 99:e90-93.

2013

Hebel K, Pierau M, Lingel H, Steiner M, Krause H, Jorch G, Brunner-Weinzierl MC. 2013. The neonatal immune system: modulation by regulatory T-cells and CTLA-4. J Laboratory Medicine 3:131.

Gimsa U, Mitchison NA, Brunner-Weinzierl MC. 2013. Immune privilege as an intrinsic CNS property: astrocytes protect the CNS against T-cell-mediated neuroinflammation. Mediators Inflamm 320519.

Schwaiger T, van den Brandt C, Fitzner B, Zaatreh S, Kraatz F, Dummer A, Nizze H, Evert M, Bröker B, Brunner-Weinzierl MC, Salem T, Lerch MM, Jaster R and Mayerle J.  (2013) Autoimmune pancreatitis in MRL/Mp mice is a T-cell mediated disease responsive to cyclosporine A and rapamycin treatment. Gut  63:494-505.

Atanackovic D, Nowottne U, Freier E, Weber CS, Meyer S, Bartels K, Hildebrandt Y, Cao Y, Kröger N, Brunner-Weinzierl MC, Bokemeyer C, Deter HC. 2013. Acute psychological stress increases peripheral blood CD3±CD56± natural killer T cells in healthy men: possible implications for the development and treatment of allergic and autoimmune disorders. Stress 16:421-428.

Smida M, Cammann C., Gurbiel S, Kerstin N, Lingel H, Lindquist S, Simeoni, L, Brunner-Weinzierl MC, Suchanek M, Schraven, B, Lindquist, JA. 2013. PAG/Cbp suppression reveals a contribution of CTLA-4 to setting the activation threshold in T cells.  Cell Commun Signal 11:28.

2012

Körmendy D, Hoff H, Hoff P, Bröker BM, Burmester GR and Brunner-Weinzierl MC. 2012. The impact of the CTLA-4/CD28 axis on the processes of Joint Inflammation in Rheumatoid Arthritis. Arthritis & Rheuma 65:81-87.

Wienecke J, Hebel K, Hegel K, Pierau M, Brune T, Reinhold D, Pethe A and Brunner-Weinzierl MC.  2011. Pro-inflammatory effector Th cells transmigrate through anti-inflammatory environments into the murine fetus. Placenta 33:39-46.

Knieke K, Lingel H, Chamaon K and Brunner-Weinzierl MC.  2012. Migration of Th1 lymphocytes is regulated by CD152 (CTLA-4)-mediated signaling via PI3 kinase-dependent Akt activation. PloS ONE 7:e313914.

Thaventhiran JE, Hoffmann A, Magiera L, de la Roche M, Lingel H, Brunner-Weinzierl MC and Fearon DT.  2012. Activation of the Hippo pathway by CTLA-4 regulates the expression of Blimp-1 in the CD8+ T cell. Proc Natl Acad Sci U S A. 109:E2223-2229.

Gieseler S und Brunner-Weinzierl MC.  2012. Kinder zeigen erhöhtes Infektionsrisiko unter Intensivtherapie. Deutscher Ärzte-Verlag DIVI 3:64-67.

2011

Kolar P, Hoff H, Maschmeyer P, Burmester GR and Brunner-Weinzierl MC.  2011. CTLA-4 (CD152) blockade does not cause a pro-inflammatory cytokine profile in regulatory T cells. Clin Exp Rheumatol 29:254-260.

Rudolph M, Hebel K, Miyamura Y, Maverakis E and Brunner-Weinzierl MC.  2011. Blockade of CTLA-4 decreases the generation of multifunctional memory CD4+ T cells in vivo. J Immunol 186:5580-5589.

Hebel K, Rudolph M and Brunner-Weinzierl MC.  2011. IL-1β and TGF-β act antagonistically in induction and differentially in propagation of human proinflammatory precursor CD4+ T cells. J Immunol 187:5627-5635.

Neumann M, Klar S, Wilisch-Neumann A, Hollenbach E, Kavuri S, Leverkus M, Kandolf R, Klingel K and Brunner-Weinzierl MC. 2011. Glycogen synthase kinase-3β is a crucial mediator of signal-induced RelB degradation. Oncogene 30:2485-2492.

Brunner-Weinzierl MC. 2011. Infektionsrisiko unter Intensivtherapie. DIVI. Spectator- Congress 11/12 2011.

2010

Luna RM, Körmendy D and Brunner-Weinzierl MC.  2010. Female-biased incidence of Experimental Autoimmune Encephalomyelistis refects sexual dimorphic expression of CTLA-4 (CD152) on T-lymphocytes. Gender Medicine 7: 296-308.     

Schnee B, Marangolo M, Bokemeyer C, Deter HC, Freier E, Weber CS, Nowottne U, Horn C, Meyer S, Hildebrandt Y, Luetkens T, Cao Y, Pabst C, Muzzulini J, Schnee B, Brunner-Weinzierl MC, Marangolo M, Deter HC and Atanackovic D.  2010. Decrease of CD4(+)FOXP3(+) T regulatory cells in the peripheral blood of human subjects undergoing a mental stressor. Psychoneuroendocrinol 35:663-673.

2009

Kolar P, Hoff H, Knieke K, Burmester GR and Brunner-Weinzierl MC.  2009. CTLA-(CD152) controls homeostasis and supressive capacity of regulatory T cells. Arthritis & Rheuma 60:123-132.

Hegel JK, Knieke K, Kolar P, Reiner SL and Brunner-Weinzierl MC.  2009. CD152 (CTLA‐4) regulates effector functions of CD8+ T lymphocytes by repressing Eomesodermin. Eur J Immunol 39:883-893.

Knieke K, Hoff H, Quandt D, Kolar P and Brunner-Weinzierl MC.  2009. CD152 (CTLA-4) determines CD4 T cell migration in vitro and in vivo. PloS ONE 4:e5702.

Freier E, Weber CS, Nowottne U, Horn C, Bartels K, Meyer S, Hildebrandt Y, Luetkens T, Cao Y, Pabst C, Muzzulini J, Schnee B, Brunner-Weinzierl MC, Marangolo M, Bokemeyer C, Deter HC and Atanackovic D.  2009. Decrease of CD4+FOXP3+ peripheral T regulatory cells during a stress-induced activation of the adaptive immune response. Psychoneuroendocrinol 35:663-673.

Hoff H, Cabail Z, Hirseland H, Knieke K, Vratsanos G, Burmester GR, Nadler SG, Bröker B, Hebel K and Brunner-Weinzierl MC.  2009. Surface CD152 (CTLA-4) expression and signaling dictates longevity of CD28null T cells. J Immunol 182: 5342-5351. 

Hoff H, Kolar P, Ambach A, Radbruch A and Brunner-Weinzierl MC.  2009. CTLA-(CD152) inhibits T cell function by activating the ubiquitin ligase ITCH. Mol Immunol 47:1875-1881.

Kolar P, Hoff H, Knieke K, Burmester GR and Brunner-Weinzierl MC. 2009. Comment: Regulatory T-cells: CTLA-4 (CD152) in the spotlight. Arthritis & Rheuma 60:2849-285.

Hegel J, Pick J, Hebel K, Krause H, Reiner S and Brunner-Weinzierl MC.  2009. Effector functions of CD8+ T-cells are controlled by costimulation targeting Eomesodermin: Implications for tumor therapy. Annex of the Proceedings of the 16th European Immunology Meeting - EFIS. Monduzzi editore. Bolognia, Italy

Hebel K, Zulema C, Burmester GR, Jorch G, Hirseland H, Vratsanos G, Nadler S and  Brunner-Weinzierl MC. 2009. The biological CTLA4Ig reduces CD28 null T cells in a patient suffering from RA: a new way of therapy. Annex of the Proceedings of the 16th European Immunology Meeting - EFIS. Monduzzi editore. Bolognia, Italy.

2007

Hoff H and Brunner-Weinzierl MC.  2007. The tyrosine phosphatase SHP-2 regulates differentiation and apoptosis of individual primary T-lymhocytes. Eur J Immunol. 37:1072-1086.       

Pandiyan P, Hegel JK, Krueger M, Quandt D and Brunner-Weinzierl MC.  2007. High IFN-gamma production of individual CD8 T lymphocytes is controlled by CD152 (CTLA-4). J Immunol 178:2132-2140.

Quandt D, Holger H, Fillatraeu S, Radbruch A and Brunner-Weinzierl MC.  2007. A new role for CD152 (CTLA-4) in B cells of TD immune responses in vivo. J Immunol 179:7316-7324.

2006

Gartner D, Hoff H, Gimsa U, Burmester GR and Brunner-Weinzierl MC. 2006. CD25 regulatory T cells determine secondary but not primary remission in EAE: Impact on long-term disease progression. J Neuroimmunol 172: 73-84.

Atanackovic D, Schnee B, Schuch G, Faltz C, Schulze J, Weber CS, Schafhausen P, Bartels K, Bokemeyer C, Brunner-Weinzierl MC and Deter HC.  2006. Acute psychological stress alerts the adaptive immune response: Stress-induced mobilization of effector T cells. J Neuroimmunol 176: 141-152.

2004

Gimsa U, Pandiyan P, Nitsch R and Brunner-Weinzierl MC.  2004. Astrocytes protect the CNS: antigen-specific T helper cell responses are inhibited by astrocyte-induced upregulation of CTLA-4 (CD152). J Mol Med 82:364-372.

Pandiyan P, Gärtner D, Soezeri O, Radbruch A, Schulze-Osthoff K and Brunner-Weinzierl MC.  2004. CD152 (CTLA-4) determines the unequal resistance of Th1 and Th2 cells against activation-induced cell death by a mechanism requiring PI3´kinase function. J Exp Med 199: 831-842.

Brunner-Weinzierl MC, Hoff H and Burmester GR. 2004. Multiple functions for CD28 and cytotoxic T lymphocyte antigen-4 during different phases of T cell responses: implications for arthritis and autoimmune diseases. Arthritis Res Ther 6:45-54.

2003

Atanackovic D, Schulze J, Kröger, H, Brunner-Weinzierl MC and Deter HC.  2003. Acute psychological stress induces a prolonged suppression of the production of reactive oxygen species by phagocytes. J Neuroimmunol 142:159-165.

Maszyna F, Kunkel D, Radbruch A and Brunner-Weinzierl MC.  2003. Diversity of clonal T cell proliferation is mediated by differential expression of CD152 (CD152) on the cell surface of activated individual T lymphocytes J Immunol 171:3459-3466.

2002

Lehmann J, Huehn J, de la Rosa M, Maszyna F, Veitt K, Brunner-Weinzierl MC, Scheffold A and Hamann A. 2002. Expression of the integrin E7 defines a unique subset of CD25+ as well as CD25- regulatory T cells. PNAS 99: 31031-31036.

Atanackovic D, Brunner-Weinzierl MC, Kröger H, Serke S and Deter HC.  2002. Acute psychological stress simultaneously alters hormone levels, recruitment of lymphocyte subsets, and production of reactive oxygen species. Immunol Invest 32: 73-91.

1999

Brunner MC, Chambers C, Chan F, Winoto A and Allison JP.  1999. CTLA-4 mediated inhibition of early events of T cell proliferation. J. Immunol. 162: 5813-5820.

Brunner MCCostimulatory molecules and modulation. The Immunologist 7: 9-12

1996

Brunner-MC, Larsen S, Sette A and Mitchison NA.  1996.  Altered Th1/Th2 balance associated with the immunosuppressive/protective effect of the H-2Ab allele on the response to allo-4-hydroxyphenylpyruvate dioxygenase.  Euro J Immunol   25:3285-3289.

Brunner MC and Mitchison NA.  1996.  Control by non-MHC genes of the allo-4-hydroxyphenylpyruvate dioxygenase (F-protein) response. Immunology  88:452-455.

Allison JP, Chambers CA, Hurwitz A, Sullivan TJ, Boitel B,  Fournier S, Brunner MC and Krummel MF.  1998. A role for CD152-mediated inhibitory signals in peripheral T cell tolerance? Immunological Tolerance. Novartis Foundation. John Wiley and Sons, Inc., New York, Weinheim, Brisbane, Singapore, Toronto.

Chambers CA, Krummel MF, Boittel B, Hurwitz A, Sullivan TJ, Fournier S, Cassell D, Brunner, MC and Allison JP.  1996.  The role of CD152 in the regulation and initiation of T cell responses. Immunol Rev 153:27.

1995

Mitchison NA and Brunner MC. 1995.  Protection against collagen-induced arthritis by H-2Ab: A possible role for the MHC class II promoter.  Immunogenetics  41:239-245.

Brunner MC. 1995. T-cell cytokine responses associated with a protective major histocompatibility complex class II allele. Dissertation, Freie Universität Berlin.

Bayrak S, Bregulla M, Brunner MC, Mitchison NA and Schneider SC. 1995. New principles in self-tolerance and autoimmunity: First-Past-the-Post, inhibitory cytokines mediating protection by major histocompatibility complex gene, triggered by infection.  Immunol Res  S1:568, S. Karger AG, Basel

1994

Brunner MC, Schneider SC and Mitchison NA.  1994. The integrative activity of the immune system.  Scand J Immunol 40:479-80.

Brunner MC, Mitchison NA and Schneider SC.  1994. Immunoregulation mediated by T cell clusters. Folia biologica  40:359-69.

Brunner MC, Mitchison NA, Sieper J and Simon K.  1994.  Cytokine profile as a predisposing or protective factor in immunological diseases: present information, prospects for intervention, the need for cytokine-based epidemiology.  Immunotherapy of Infections.  Chapter 3, Marcel Dekker, Inc., New York.

1992

Brunner MC.  1992.  Charakterisierung des C-terminalen, Rezeptor-bindenden Areals des Anaphylatoxins C3a mit Hilfe von synthetischen Peptiden und monoklonalen Antikörpern. Diplomarbeit. Freie Universität Berlin.

Brunner MC, Caput D, Helbert M, Mitchison NA, Simon K and Wu P,  1992.  Regulation of regulatory T-cells. Progress in Immunol  7:627.

 

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